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10.1016/j.actbio.2017.09.035 Acta Biomater

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Specific and moderate manipulation of activities of LOXs and transcriptional regulation of hypoxia-responsive transcription factors through copper bioavailability modulation or continuous hypoxia-conditioning may become effective interventions for enhanced cartilage regeneration, as well as promising rejuvenation therapeutics, which may exert further therapeutic implications in the upcoming clinical arena
