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6.2 PNS and Parkinsons disease (PD) PD is a neurodegenerative disorder in which the balance between dopamine and acetylcholine is dysregulated due to degenerative changes in dopamine (DA) neurons in the dense nigrostriatal region of the midbrain (Marino et al., 2020)

Prior to all differential abundance analyses, metabolite features with zero variance across the considered samples were removed

In human TS studies, metabolite correlations similar in microbiome to our findings have been observed, particularly regarding reduced SCFAs levels, dysregulation of tryptophan metabolism and abnormal glutamate-GABA balance

Bibcode:2019NatCo..10.3892S

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Hallaji M., Allahyri M., Teimoori-Toolabi L., Yasami-Khiabani S., Golkar M., Fard-Esfahani P
