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Pentosan polysulfate was endorsed by the US Food and Drug Administration (FDA) in 1996 and remains the only treatment approved for interstitial cystitis

10.1073/pnas.0505256102

Mild soreness or redness at the injection site is possible, but this typically resolves quickly and doesnt interrupt normal activities 3

Thereby, in ketamine-rat, BPC 157 therapy was able to affect all negative-like symptoms in the same way (i.e., BPC 157 counteracts cognition deficit, social withdrawal, anhedonia and has an additional anxiolytic effect), L-arginine and L-NAME could ameliorate some but worsen others [59]

This mechanistic uncertainty limits interpretation of human efficacy data