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Redman, L

Furthermore, their quinidinelike effect on cardiac conduction, which can prolong the QTc interval, necessitates careful cardiovascular screening and often precludes their use in elderly patients or those with preexisting heart disease, frequently positioning them as a secondary choice after SNRIs or gabapentinoids [45, 336, 368, 369]

[DOI] [PMC free article] [PubMed] [Google Scholar] 352.Okugawa S., Ota Y., Kitazawa T., Nakayama K., Yanagimoto S., Tsukada K., Kawada M., Kimura S

BPC-157: not FDA-approved

Taken together, the current comprehensive studies, together with previous reports 12,15,16,17 , establish the suppression of AGXT and enhanced activity of LDHA as the underlying mechanisms for the overproduction of oxalate in MASH