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Particularly, it determined the upregulation of ROS-scavenging enzymes, anti-inflammatory cytokines, (IL-10, IL-6 and PPAR ), tight junctions proteins, such as ZO-1, MUC-2, claudin-3, and the downregulation of inflammatory genes (TNF-, IL-1) [14]

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The further roles of NNMT in regulating glucose metabolism and the related mechanisms are mainly from Kraus et al

Due to our strict requirement for explicit details of dosage and routes, our search yielded 27 studies with a total of 34 patients, which is a comparatively small sample size