who can administer a b12 injection How to self-inject intramuscular vitamin - Overview Administering a B12 Injection Safely

Cyanocobalamin should not be used in patients who are pregnant and in patients with early hereditary optic nerve atrophy and cyanocobalamin hypersensitivity

Low vitamin B12 has recently been linked to chronic migraine, and high homocysteine, with low cofactors and alterations in MTHFR (remember, the one that allowed the passage of THF to M-THF), has been linked to migraine with aura, due to incorrect methionine synthesis, which ultimately leads to an increase in homocysteine, causing an increase in reactive oxygen species (causing oxidative stress)

Global deletion of monoacylglycerol lipase in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity

smaller doses given more frequently)

There is a fine balance here, however as too much methionine is also not good