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A phase I clinical trial of patients with recurrent head and neck cancer demonstrated that the combination of COX-2 inhibitors (erlotinib, celecoxib) and radiotherapy can improve progression-free survival (37%) and overall survival (55%) [163]

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[240] [241] [242] Some evidence suggests that amphetamine may be more strongly modulated by ovarian sex hormones than other psychostimulants such as methylphenidate, which may result in relatively greater variability in drug response across the menstrual cycle

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