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Over enough time, this can cause the following: Refusal to use their regular water and food bowls They may pace and meow in front of their feeding station They may attempt to spill or dig out their food from their bowls Aggressive behavior has been noted with some cats when they have been given food or treats outside of their feeding bowls The process of combating whisker fatigue is simple

Clin Endocrinol (2011) 75(1):705

Store under refrigeration 2 to 8C (36 to 46F)

These symptoms typically diminish over 48 weeks as tolerance develops

In acute treatment, a significant decrease in the globus pallidus, dorsal and ventral hippocampus, dorsal thalamus, lateral geniculate body, and hypothalamus [67]