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[DOI] [PubMed] [Google Scholar] 109.Sirrs S., Duncan L., Djurdjev O., Nussbaumer G., Ganz G., Frohlich J., Levin A
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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
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A healthy immune system A healthy immune system is critical through every stage of life, but it's hard to keep in tip-top shape
