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Moreover, no signs of inflammation were observed in nasal mucosa of co-modified-BM-loaded PLGA-treated mice, suggesting a safe and non-invasive strategy for intranasal delivery 127
This aggressive first-pass metabolism slashes its plasma half-life to a meagre 30 minutes, reducing its chances of reaching peripheral nerves or muscle tissues in therapeutic amounts
10.1002/stem.1878 160 WangK.JiangZ.WebsterK

These HED calculations are illustrative anchors for hypothesis generation only and are not clinical dosing recommendations
J Nanobiotechnol 15:112 Squires JE, Berry MJ (2008) Eukaryotic selenoprotein synthesis: mechanistic insight incorporating new factors and new functions for old factors
