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ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

The products for the entire intervention period were provided at the end of each baseline visit, to be consumed once during the daytime with a glass of water and the standardized snack to increase absorption of vitamin B12

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Piperine promotes autophagy flux by P2RX4 activation in SNCA/-synuclein-induced Parkinson disease model

Therefore, targeting PTGS2 is essential for inhibiting ferroptosis