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doi: 10.2337/dc13-2760 [DOI] [PubMed] [Google Scholar] 219

Although GLP-1RAs show promise in enhancing mitochondrial health, major gaps remain in understanding cell-type-specific responses, sex- and age-related differences, and the precise mechanistic links between GLP-1 signaling in mitochondrial biogenesis, dynamics, and mitophagy

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In humans, C-cells contain far fewer GLP-1 receptors, which suggests a much lower risk for similar outcomes

the SNPs were clumped for linkage disequilibrium (clumping R 2 = 0.01) (4) Calculated the F-statistics (beta 2 /SE 2 ) of SNP and excluded SNP with values less than 10 to avoid weak instrumental variable bias (5)