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[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Honigberg MC, et al
In the past ten years, a series of Phase III trials showed that the synthetic GLP-1/GIP agonists are effective in lowering blood sugar in type 2 diabetic subjects who were both treatment-nave or on typical first-line therapies such as metformin and insulin

Diphtheria toxin-induced ablation of GLP-1 producing neurons in the NTS had no effect on either ad libitum food intake or glucose metabolism [90]

The trial results showed by those on the lowest dose cut their glycated haemoglobin level by an average of 1.24 percentage points compared to 1.47 percentage points with the 12-mg dose, and 1.48 percentage points on the 36-mg dose

The Journal of Pharmacy Technology
