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GLP-1 RAs are increasingly used in the treatment of T2DM due to their multifaceted benefits, including improving glycemic control, reducing body weight, enhancing -cell function, and yielding favorable cardiovascular and renal outcomes [22]

Jill Corleone, RD Medical Reviewer Jill is a registered dietitian and health writer based in Honolulu

Additionally, a large-scale observational study involving over 40,000 Chinese OA patients with comorbid T2DM reported that GLP-1RA therapies offered disease-modifying benefits [49]

The MR method showed a significant association between GLP-1RA and reduced risk of DR (OR = 0.59, 95%CI: 0.390.89, P = 0.0109), in addition, similar results were also found with the SMR method (OR = 0.48, 95%CI: 0.270.86, P = 0.0129)

doi: 10.1111/micc.12492 25