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thus, glomerular pressure increases and leads to glomerular hyperfiltration until organ damage develops [84]

These effects explain why gastrointestinal side effects are among the most commonly reported adverse reactions to GLP-1 therapy

These are crucial for the enzymes activity and are situated within a specific structural motif known as the a/b-hydrolase loop

7) dipeptidyl peptidase-4

J Biol Chem 261: 11880-11889, 1986