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Description
The disorder is mostly asymptomatic [27]

Soluble epoxide hydrolase (sEH), encoded by the Ephx2 gene, is a widely distributed enzyme that catalyzes the hydrolysis of epoxy fatty acids (EpFA), such as epoxyeicosatrienoic acids [EETs, metabolized from arachidonic acid (AA)] produced by cytochrome P450 enzymes to their corresponding diols [i.e., dihydroxyeicosatrienoic acids (DHETs)]
Shen Z, Song J, Yung BC, Zhou Z, Wu A, Chen X

In hyperadrenergic POTS autoantibodies accentuate expression (Wirth & Scheibenbogen, 2020)
When inhaled through a nebulizer, it enters the bloodstream rapidly through the lungs for efficient absorption and enhanced biological activity
