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for example, Lilly expects to share Phase 3 obesity data on orfoglipron, an oral GLP-1 agonist, and retatrutide, a triple agonist of GLP/GIP/glucagon receptors in 2025 3 Xie, Y., Choi, T., & Al-Aly, Z

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GLP-1 is a peptide hormone consisting of 30 amino acids derived from glucagonogen, which is processed by the differentiation of the glucagonogen gene expressed by intestinal epithelial endocrine L-cells, and has two biologically active forms, GLP-1 (736 amide) and GLP-1 (7-37), and the intestine is the major source of GLP-1 in plasma (Mller et al., 2019