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Vitamin B6: Though some research suggests vitamin B6 could help alleviate some of the emotional symptoms of PMDD, the small amount in this supplement is most likely added to help the body better metabolize the supplemental 5-HTP into serotonin.64 65 Lions mane: While research is still emerging, lions mane may help support mood and reduce inflammation.66 The amount included here is relatively modest compared to doses used in clinical studies, so it likely plays more of a supporting role in the formula

is supported by grants from the US National Institutes of Health (grants R37 CA50286, R01 CA95262, R01 CA45726, P01 HL57900 and R01 HL103956)

International journal of molecular sciences, 19(7), 1987

This is significant as the gut microbiota has been implicated in the pathogenesis of metabolic diseases