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This in turn causes unacceptable glucose oscillations due to a high rate of serious hypoglycemic episodes followed by rebound glucose spikes whenever patients suddenly switch from affected injection sites to normal ones

In sheer numbers, that means that while 8,722 Americans in this age group took a GLP-1 in 2020, 60,567 were doing so by the end of 2023

One key effect is slowing gastric emptying, which means food stays in your stomach longer than usual

NYU Langone Health / NYC Health + Hospitals

Among 47 cases with patients with confirmed MCAS, many of whom had not responded adequately to prior therapies, the case series found that 89% demonstrated clinical benefit with GLP-1RAs across a broad range of symptoms