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A 2023 review in Frontiers in Physiology noted that mitochondrial-derived peptides like MOTS-c represent a functionally separate class from growth-hormone-axis compounds such as Tesamorelin underscoring why comparison, rather than substitution, is the right framework for evaluating them

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5A-1MQ-treated mice switched from WD to LD were particularly distinct from mice in the other groups when k-means clustering was applied to the ASV relative abundance data