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A 2021 systematic review and meta-analysis published in the International Forum of Allergy and Rhinology confirmed that botulinum toxin type A improved total nasal symptom scores and quality of life in patients with chronic rhinitis with effects demonstrated up to 24 weeks post-treatment in some studies

First: PI3K/Akt/mTOR, which drives protein synthesis, glucose uptake (via GLUT4 translocation), and anti-apoptotic signaling (particularly relevant in muscle and neuronal tissue)

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