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Common side effects include nausea, vomiting, diarrhea, and constipation, with potential serious risks including pancreatitis and gallbladder disease
The mechanisms accounting for this improvement is uncertain but could be related to reductions in glycated hemoglobin, body weight, systolic blood pressure, postprandial triglyceride levels, inflammation, or the direct effect of activation of GLP-1 receptors on the myocardium

The CCKBR gene is located on chromosome 11p15.4 and is composed of 4 exons that generate three alternatively spliced mRNAs, each of which encodes a distinct protein isoform

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Jayachandran M., Xiao J.B., Xu B.J

Weight regain after discontinuation Within a year of stopping GLP-1 therapy, 49% of patients were heavier than when they started (Abdel-Bary et al