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These peptides have been studied well in the past century
P.Fernndez LandL.BrownK.et al (2021)

Inflammasomes as therapeutic targets in human diseases

These effects are observed across substances and models, including operant self-administration, CPP, reinstatement paradigms, and neurochemical readouts

The newer anti-obesity medications (AOMs), like the GLP-1 medications indicated for weight loss (i.e., Wegovy and Saxenda ), appear to provide a new hope for many, although they still come with some gastrointestinal side effects
